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Cost (lowest expected): 616,500 iron bits

(3) Ancient Heart

(9) Blood of Ch'thon

(4) Manticore Eye

(10) Tainted Brain Matter

(1) Troll Bonecrusher

Relic Crafting Order: Annihilation

Stage 1

Calamity

Empowered (18)

8,000 Iron Bits

Ruination

Empowered (18)

8,000 Iron Bits

Inferno

Empowered (25)

15,000 Iron Bits

Stage 2

Ruination

Empowered (18)

8,000 Iron Bits

2

Inferno

Empowered (25)

15,000 Iron Bits

Mistborn Talisman

Empowered (25)

15,000 Iron Bits

2

Rampage

Empowered (25)

15,000 Iron Bits

Squall

Empowered (25)

15,000 Iron Bits

Conflagration

Transcendent (35)

37,500 Iron Bits

Required Relics

Stage 3

Bladesworn Talisman

Empowered (25)

15,000 Iron Bits

Inferno

Empowered (25)

15,000 Iron Bits

Savage

Transcendent (35)

37,500 Iron Bits

Required Relics

Slaughter

Transcendent (35)

37,500 Iron Bits

Required Relics

Desolation

Transcendent (50)

66,000 Iron Bits

Required Relics

Stage 4

Gunslinger's Talisman

Empowered (25)

8,000 Iron Bits

Zeal

Transcendent (50)

66,000 Iron Bits

Required Relics

Ulzuin's Pyroclasm

Mythical (60)

105,000 Iron Bits

Required Relics

Stage 5

Annihilation

Mythical (70)

130,000 Iron Bits

Required Relics